In the Standard Model there are 28 fundamental constants, like the finestructure constant. 22 of these constants are given by the lepton and quark masses, and the related flavor mixing parameters.
In the SO(10) Grand Unified Theory the flavor mixing parameters are fixed by the ratios of the fermion masses. I will discuss the
success of such a model for the quarks and apply the same idea to the leptons. Using the experimental values for the neutrino mixing angles, I can calculate the neutrino masses. The are very small - the mass of the third neutrino is only 0.05 eV. It will be very difficult to find an effect in the neutrinoless double beta decay. One prediction can soon be checked in the new reactor neutrino experiments.